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Literature summary for 4.2.1.9 extracted from

  • Oliver, J.D.; Kaye, S.J.; Tuckwell, D.; Johns, A.E.; Macdonald, D.A.; Livermore, J.; Warn, P.A.; Birch, M.; Bromley, M.J.
    The Aspergillus fumigatus dihydroxyacid dehydratase Ilv3A/IlvC is required for full virulence (2012), PLoS ONE, 7, e43559.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
recombinant expression in Escherichia coli as a His-tagged fusion protein Aspergillus fumigatus

Inhibitors

Inhibitors Comment Organism Structure
2-hydroxy-3-methylbutyric acid
-
Aspergillus fumigatus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
10.1
-
L-threonate pH 8, 22°C Aspergillus fumigatus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion predicted localisation Aspergillus fumigatus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
65000
-
SDS-PAGE, recombinant enzyme Aspergillus fumigatus

Organism

Organism UniProt Comment Textmining
Aspergillus fumigatus
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
18
-
pH 8, 22°C Aspergillus fumigatus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-threonate
-
Aspergillus fumigatus ?
-
?

Synonyms

Synonyms Comment Organism
AfIlv3A
-
Aspergillus fumigatus
AFUA_2G2410
-
Aspergillus fumigatus
DHAD
-
Aspergillus fumigatus
dihydroxyacid dehydratase
-
Aspergillus fumigatus
ilvC
-
Aspergillus fumigatus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
8
-
pH 8, 22°C Aspergillus fumigatus 2-hydroxy-3-methylbutyric acid

General Information

General Information Comment Organism
malfunction deletion Dilv3A strain requires supplementation with isoleucine and valine for growth Aspergillus fumigatus
malfunction mutants lacking AfIlv3A and ilv3B exhibit reduced levels of virulence in murine infection models Aspergillus fumigatus