Application | Comment | Organism |
---|---|---|
synthesis | bioconversion of 3-cyanopyridine using the in situ nitrile hydratase-amidase cascade system of resting Microbacterium imperiale CBS 498-74 cells in an ultrafiltration-membrane reactor, carried out in continuously stirred tank UF-membrane bioreactors arranged in series, the reactor configuration enables both enzymes, involved in the cascade reaction, to work with optimized kinetics, without any purification, exploiting their differing temperature dependences, method optimization, overview | Microbacterium imperiale |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-cyanopyridine + H2O | Microbacterium imperiale | NHase-AMase cascade system exploited in a continuous reactor configuration, including nitrile hydratase and amidase, EC 3.5.1.4, activity. Bioconversion to intermediate nicotinamide and further to nicotinic acid | nicotinamide | - |
? | |
3-cyanopyridine + H2O | Microbacterium imperiale CBS 498-74 | NHase-AMase cascade system exploited in a continuous reactor configuration, including nitrile hydratase and amidase, EC 3.5.1.4, activity. Bioconversion to intermediate nicotinamide and further to nicotinic acid | nicotinamide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Microbacterium imperiale | - |
- |
- |
Microbacterium imperiale CBS 498-74 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-cyanopyridine + H2O | - |
Microbacterium imperiale | nicotinamide | - |
? | |
3-cyanopyridine + H2O | NHase-AMase cascade system exploited in a continuous reactor configuration, including nitrile hydratase and amidase, EC 3.5.1.4, activity. Bioconversion to intermediate nicotinamide and further to nicotinic acid | Microbacterium imperiale | nicotinamide | - |
? | |
3-cyanopyridine + H2O | - |
Microbacterium imperiale CBS 498-74 | nicotinamide | - |
? | |
3-cyanopyridine + H2O | NHase-AMase cascade system exploited in a continuous reactor configuration, including nitrile hydratase and amidase, EC 3.5.1.4, activity. Bioconversion to intermediate nicotinamide and further to nicotinic acid | Microbacterium imperiale CBS 498-74 | nicotinamide | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
5 | - |
bioconversion in cells in a bioreactor | Microbacterium imperiale |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
bioconversion in cells in a bioreactor | Microbacterium imperiale |