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Literature summary for 4.2.1.78 extracted from

  • Li, J.; Lee, E.J.; Chang, L.; Facchini, P.J.
    Genes encoding norcoclaurine synthase occur as tandem fusions in the Papaveraceae (2016), Sci. Rep., 6, 39256 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli and in Saccharomyces cereviseae Thalictrum flavum
expression in Escherichia coli and in Saccharomyces cereviseae Papaver somniferum
expression in Escherichia coli and in Saccharomyces cereviseae Nandina domestica
expression in Escherichia coli and in Saccharomyces cereviseae Corydalis chinensis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.347
-
dopamine pH 7.3, 37°C Nandina domestica
0.48
-
4-hydroxyphenylacetaldehyde pH 7.3, 37°C Nandina domestica
0.502
-
dopamine pH 7.3, 37°C Corydalis chinensis
1.829
-
4-hydroxyphenylacetaldehyde pH 7.3, 37°C Corydalis chinensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-hydroxyphenylacetaldehyde + dopamine Thalictrum flavum the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis (S)-norcoclaurine + H2O
-
?
4-hydroxyphenylacetaldehyde + dopamine Papaver somniferum the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis (S)-norcoclaurine + H2O
-
?
4-hydroxyphenylacetaldehyde + dopamine Nandina domestica the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis (S)-norcoclaurine + H2O
-
?
4-hydroxyphenylacetaldehyde + dopamine Corydalis chinensis the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis (S)-norcoclaurine + H2O
-
?

Organism

Organism UniProt Comment Textmining
Corydalis chinensis
-
-
-
Nandina domestica
-
-
-
Papaver somniferum Q4QTJ1
-
-
Papaver somniferum Q4QTJ2
-
-
Thalictrum flavum Q67A25
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-hydroxyphenylacetaldehyde + dopamine
-
Thalictrum flavum (S)-norcoclaurine + H2O
-
?
4-hydroxyphenylacetaldehyde + dopamine
-
Papaver somniferum (S)-norcoclaurine + H2O
-
?
4-hydroxyphenylacetaldehyde + dopamine
-
Nandina domestica (S)-norcoclaurine + H2O
-
?
4-hydroxyphenylacetaldehyde + dopamine
-
Corydalis chinensis (S)-norcoclaurine + H2O
-
?
4-hydroxyphenylacetaldehyde + dopamine the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis Thalictrum flavum (S)-norcoclaurine + H2O
-
?
4-hydroxyphenylacetaldehyde + dopamine the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis Papaver somniferum (S)-norcoclaurine + H2O
-
?
4-hydroxyphenylacetaldehyde + dopamine the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis Nandina domestica (S)-norcoclaurine + H2O
-
?
4-hydroxyphenylacetaldehyde + dopamine the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis Corydalis chinensis (S)-norcoclaurine + H2O
-
?

Synonyms

Synonyms Comment Organism
CCHNCS2
-
Corydalis chinensis
NDONCS3
-
Nandina domestica
PSONCS1
-
Papaver somniferum
PSONCS2
-
Papaver somniferum
TFLNCSDELTA25
-
Thalictrum flavum

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.7
-
4-hydroxyphenylacetaldehyde pH 7.3, 37°C Nandina domestica
2.4
-
dopamine pH 7.3, 37°C Nandina domestica
5.3
-
4-hydroxyphenylacetaldehyde pH 7.3, 37°C Corydalis chinensis
5.8
-
dopamine pH 7.3, 37°C Corydalis chinensis

General Information

General Information Comment Organism
metabolism the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis Thalictrum flavum
metabolism the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis Papaver somniferum
metabolism the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis Nandina domestica
metabolism the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis Corydalis chinensis