Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli and in Saccharomyces cereviseae | Thalictrum flavum |
expression in Escherichia coli and in Saccharomyces cereviseae | Papaver somniferum |
expression in Escherichia coli and in Saccharomyces cereviseae | Nandina domestica |
expression in Escherichia coli and in Saccharomyces cereviseae | Corydalis chinensis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.347 | - |
dopamine | pH 7.3, 37°C | Nandina domestica | |
0.48 | - |
4-hydroxyphenylacetaldehyde | pH 7.3, 37°C | Nandina domestica | |
0.502 | - |
dopamine | pH 7.3, 37°C | Corydalis chinensis | |
1.829 | - |
4-hydroxyphenylacetaldehyde | pH 7.3, 37°C | Corydalis chinensis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-hydroxyphenylacetaldehyde + dopamine | Thalictrum flavum | the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis | (S)-norcoclaurine + H2O | - |
? | |
4-hydroxyphenylacetaldehyde + dopamine | Papaver somniferum | the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis | (S)-norcoclaurine + H2O | - |
? | |
4-hydroxyphenylacetaldehyde + dopamine | Nandina domestica | the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis | (S)-norcoclaurine + H2O | - |
? | |
4-hydroxyphenylacetaldehyde + dopamine | Corydalis chinensis | the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis | (S)-norcoclaurine + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Corydalis chinensis | - |
- |
- |
Nandina domestica | - |
- |
- |
Papaver somniferum | Q4QTJ1 | - |
- |
Papaver somniferum | Q4QTJ2 | - |
- |
Thalictrum flavum | Q67A25 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-hydroxyphenylacetaldehyde + dopamine | - |
Thalictrum flavum | (S)-norcoclaurine + H2O | - |
? | |
4-hydroxyphenylacetaldehyde + dopamine | - |
Papaver somniferum | (S)-norcoclaurine + H2O | - |
? | |
4-hydroxyphenylacetaldehyde + dopamine | - |
Nandina domestica | (S)-norcoclaurine + H2O | - |
? | |
4-hydroxyphenylacetaldehyde + dopamine | - |
Corydalis chinensis | (S)-norcoclaurine + H2O | - |
? | |
4-hydroxyphenylacetaldehyde + dopamine | the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis | Thalictrum flavum | (S)-norcoclaurine + H2O | - |
? | |
4-hydroxyphenylacetaldehyde + dopamine | the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis | Papaver somniferum | (S)-norcoclaurine + H2O | - |
? | |
4-hydroxyphenylacetaldehyde + dopamine | the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis | Nandina domestica | (S)-norcoclaurine + H2O | - |
? | |
4-hydroxyphenylacetaldehyde + dopamine | the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis | Corydalis chinensis | (S)-norcoclaurine + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CCHNCS2 | - |
Corydalis chinensis |
NDONCS3 | - |
Nandina domestica |
PSONCS1 | - |
Papaver somniferum |
PSONCS2 | - |
Papaver somniferum |
TFLNCSDELTA25 | - |
Thalictrum flavum |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.7 | - |
4-hydroxyphenylacetaldehyde | pH 7.3, 37°C | Nandina domestica | |
2.4 | - |
dopamine | pH 7.3, 37°C | Nandina domestica | |
5.3 | - |
4-hydroxyphenylacetaldehyde | pH 7.3, 37°C | Corydalis chinensis | |
5.8 | - |
dopamine | pH 7.3, 37°C | Corydalis chinensis |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis | Thalictrum flavum |
metabolism | the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis | Papaver somniferum |
metabolism | the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis | Nandina domestica |
metabolism | the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis | Corydalis chinensis |