Any feedback?
Literature summary for 4.2.1.78 extracted from
- Library of norcoclaurine synthases and their immobilization for biocatalytic transformations (2018), Biotechnol. J., 13, e1700542 .
Application
| Application | Comment | Organism |
|---|---|---|
| synthesis | the enzyme is a highly suitable catalyst for the Pictet-Spengler reaction | Argemone mexicana |
| synthesis | the enzyme is a highly suitable catalyst for the Pictet-Spengler reaction | Corydalis saxicola |
| synthesis | the enzyme is a highly suitable catalyst for the Pictet-Spengler reaction. The enzyme is successfully immobilized on various carriers whereby EziG3 proves to be the best suited for biotransformations | Papaver bracteatum |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli BL21 (DE3) | Argemone mexicana |
| expression in Escherichia coli BL21 (DE3) | Corydalis saxicola |
| expression in Escherichia coli BL21 (DE3). Under certain conditions lyophilized whole Escherichia coli cells containing the overexpressed enzyme turn out to a suitable catalysts | Papaver bracteatum |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-hydroxyphenylacetaldehyde + dopamine | Papaver bracteatum | the enzyme is involved in the biosynthesis of benzylisoquinoline | (S)-norcoclaurine + H2O | - |
? |  |
| 4-hydroxyphenylacetaldehyde + dopamine | Argemone mexicana | the enzyme is involved in the biosynthesis of benzylisoquinoline | (S)-norcoclaurine + H2O | - |
? | |
| 4-hydroxyphenylacetaldehyde + dopamine | Corydalis saxicola | the enzyme is involved in the biosynthesis of benzylisoquinoline | (S)-norcoclaurine + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Argemone mexicana | D2SMN1 | - |
- |
| Argemone mexicana | D2SMN3 | - |
- |
| Corydalis saxicola | F5C449 | - |
- |
| Papaver bracteatum | C3SBT7 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Papaver bracteatum |
- |
Argemone mexicana |
- |
Corydalis saxicola |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-hydroxyphenylacetaldehyde + dopamine | - |
Papaver bracteatum | (S)-norcoclaurine + H2O | - |
? | |
| 4-hydroxyphenylacetaldehyde + dopamine | - |
Argemone mexicana | (S)-norcoclaurine + H2O | - |
? | |
| 4-hydroxyphenylacetaldehyde + dopamine | - |
Corydalis saxicola | (S)-norcoclaurine + H2O | - |
? | |
| 4-hydroxyphenylacetaldehyde + dopamine | the enzyme is involved in the biosynthesis of benzylisoquinoline | Papaver bracteatum | (S)-norcoclaurine + H2O | - |
? | |
| 4-hydroxyphenylacetaldehyde + dopamine | the enzyme is involved in the biosynthesis of benzylisoquinoline | Argemone mexicana | (S)-norcoclaurine + H2O | - |
? | |
| 4-hydroxyphenylacetaldehyde + dopamine | the enzyme is involved in the biosynthesis of benzylisoquinoline | Corydalis saxicola | (S)-norcoclaurine + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AmNCS1 | - |
Argemone mexicana |
| AmNCS2 | - |
Argemone mexicana |
| CsNCS | - |
Corydalis saxicola |
| PbNCS | - |
Papaver bracteatum |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | the enzyme is involved in the biosynthesis of benzylisoquinoline | Argemone mexicana |
| metabolism | the enzyme is involved in the biosynthesis of benzylisoquinoline | Corydalis saxicola |
| metabolism | the enzyme is involved in the biosynthetic of benzylisoquinoline | Papaver bracteatum |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
