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Literature summary for 4.2.1.78 extracted from
- (S)-Norlaudanosoline synthase: the first enzyme in the benzylisoquinoline biosynthetic pathway (1981), FEBS Lett., 129, 5-9.
No PubMed abstract available
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1 | - |
3,4-dihydroxyphenylacetaldehyde | - |
Eschscholtzia tenuifolia |  |
| 5 | - |
4-(2-Aminoethyl)benzene-1,2-diol | - |
Eschscholtzia tenuifolia | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde | Papaver somniferum | initial reaction in isoquinoline biosynthesis | ? | - |
? | |
| 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde | Berberis regeliana | initial reaction in isoquinoline biosynthesis | ? | - |
? | |
| 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde | Capnoides sempervirens | initial reaction in isoquinoline biosynthesis | ? | - |
? | |
| 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde | Lamprocapnos spectabilis | initial reaction in isoquinoline biosynthesis | ? | - |
? | |
| 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde | Eschscholzia pulchella | initial reaction in isoquinoline biosynthesis | ? | - |
? | |
| 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde | Fumaria officinalis | initial reaction in isoquinoline biosynthesis | ? | - |
? | |
| 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde | Glaucium rubrum | initial reaction in isoquinoline biosynthesis | ? | - |
? | |
| 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde | Meconopsis cambrica | initial reaction in isoquinoline biosynthesis | ? | - |
? | |
| 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde | Ranunculus flammula | initial reaction in isoquinoline biosynthesis | ? | - |
? | |
| 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde | Thalictrum tuberosum | initial reaction in isoquinoline biosynthesis | ? | - |
? | |
| 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde | Eschscholtzia tenuifolia | initial reaction in isoquinoline biosynthesis | ? | - |
? | |
| 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde | Thalictrum minus | initial reaction in isoquinoline biosynthesis | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Berberis regeliana | - |
- |
- |
| Capnoides sempervirens | - |
- |
- |
| Eschscholtzia tenuifolia | - |
- |
- |
| Eschscholzia pulchella | - |
- |
- |
| Fumaria officinalis | - |
- |
- |
| Glaucium rubrum | - |
- |
- |
| Lamprocapnos spectabilis | - |
- |
- |
| Meconopsis cambrica | - |
- |
- |
| Papaver somniferum | - |
- |
- |
| Ranunculus flammula | - |
- |
- |
| Thalictrum minus | - |
- |
- |
| Thalictrum tuberosum | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cell culture | - |
Papaver somniferum | - |
| cell culture | - |
Berberis regeliana | - |
| cell culture | - |
Capnoides sempervirens | - |
| cell culture | - |
Lamprocapnos spectabilis | - |
| cell culture | - |
Eschscholzia pulchella | - |
| cell culture | - |
Fumaria officinalis | - |
| cell culture | - |
Glaucium rubrum | - |
| cell culture | - |
Meconopsis cambrica | - |
| cell culture | - |
Ranunculus flammula | - |
| cell culture | - |
Thalictrum tuberosum | - |
| cell culture | - |
Eschscholtzia tenuifolia | - |
| cell culture | - |
Thalictrum minus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde | - |
Papaver somniferum | (S)-norlaudanosoline + H2O | - |
? | |
| 4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde | - |
Berberis regeliana | (S)-norlaudanosoline + H2O | - |
? | |
| 4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde | - |
Capnoides sempervirens | (S)-norlaudanosoline + H2O | - |
? | |
| 4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde | - |
Lamprocapnos spectabilis | (S)-norlaudanosoline + H2O | - |
? | |
| 4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde | - |
Eschscholzia pulchella | (S)-norlaudanosoline + H2O | - |
? | |
| 4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde | - |
Fumaria officinalis | (S)-norlaudanosoline + H2O | - |
? | |
| 4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde | - |
Glaucium rubrum | (S)-norlaudanosoline + H2O | - |
? | |
| 4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde | - |
Meconopsis cambrica | (S)-norlaudanosoline + H2O | - |
? | |
| 4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde | - |
Ranunculus flammula | (S)-norlaudanosoline + H2O | - |
? | |
| 4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde | - |
Thalictrum tuberosum | (S)-norlaudanosoline + H2O | - |
? | |
| 4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde | - |
Thalictrum minus | (S)-norlaudanosoline + H2O | - |
? | |
| 4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde | i.e. dopamine + 3,4-dihydroxyphenylacetaldehyde, , 3,4-dihydroxyphenylacetaldehyde can be substituted by 4-hydroxyphenylacetaldehyde but not by 3,4-dihydroxyphenylpyruvate, 4-hydroxyphenylpyruvate or phenylpyruvate | Eschscholtzia tenuifolia | (S)-norlaudanosoline + H2O | - |
? | |
| 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde | i.e. dopamine + 4-hydroxyphenylacetaldehyde, , 4-hydroxyphenylacetaldehyde can be substituted by 3,4-dihydroxyphenylacetaldehyde but not by 3,4-dihydroxyphenylpyruvate, 4-hydroxyphenylpyruvate or phenylpyruvate | Eschscholtzia tenuifolia | (S)-Norcoclaurine + H2O | - |
? | |
| 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde | initial reaction in isoquinoline biosynthesis | Papaver somniferum | ? | - |
? | |
| 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde | initial reaction in isoquinoline biosynthesis | Berberis regeliana | ? | - |
? | |
| 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde | initial reaction in isoquinoline biosynthesis | Capnoides sempervirens | ? | - |
? | |
| 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde | initial reaction in isoquinoline biosynthesis | Lamprocapnos spectabilis | ? | - |
? | |
| 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde | initial reaction in isoquinoline biosynthesis | Eschscholzia pulchella | ? | - |
? | |
| 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde | initial reaction in isoquinoline biosynthesis | Fumaria officinalis | ? | - |
? | |
| 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde | initial reaction in isoquinoline biosynthesis | Glaucium rubrum | ? | - |
? | |
| 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde | initial reaction in isoquinoline biosynthesis | Meconopsis cambrica | ? | - |
? | |
| 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde | initial reaction in isoquinoline biosynthesis | Ranunculus flammula | ? | - |
? | |
| 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde | initial reaction in isoquinoline biosynthesis | Thalictrum tuberosum | ? | - |
? | |
| 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde | initial reaction in isoquinoline biosynthesis | Eschscholtzia tenuifolia | ? | - |
? | |
| 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde | initial reaction in isoquinoline biosynthesis | Thalictrum minus | ? | - |
? | |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | 8.5 | - |
Eschscholtzia tenuifolia |
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