Literature summary for 4.2.1.75 extracted from

Silva, P.J.; Ramos, M.J.
Comparative density functional study of models for the reaction mechanism of uroporphyrinogen III synthase (2008), J. Phys. Chem. B, 112, 3144-3148.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
hydroxymethylbilane	Homo sapiens	the D-ring of the hydroxymethylbilane substrate binds to the enzyme in a conformation that shields its terminal portion from reacting with ring A and prevents the formation of the biologically useless uroporphyrinogen I, reaction mechanism, overview	uroporphyrinogen III + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P10746	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
hydroxymethylbilane = uroporphyrinogen III + H2O	reaction mechanism, modelling, overview	Homo sapiens	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
hydroxymethylbilane	the D-ring of the hydroxymethylbilane substrate binds to the enzyme in a conformation that shields its terminal portion from reacting with ring A and prevents the formation of the biologically useless uroporphyrinogen I, reaction mechanism, overview	Homo sapiens	uroporphyrinogen III + H2O	-	?
hydroxymethylbilane	the enzyme catalyzes the inversion of one of the four heterocyclic rings present in the substrate. Reaction mechanism analysis by high-level quantum mechanical calculations on model systems of the enzyme	Homo sapiens	uroporphyrinogen III + H2O	-	?

Synonyms

Synonyms	Comment	Organism
Uroporphyrinogen III synthase	-	Homo sapiens

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Release 2023.1 (January 2023)