Protein Variants | Comment | Organism |
---|---|---|
additional information | 16 known mutations causing congenital erythropoietic porphyria in humans via alterations of the tertiary enzyme structure | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
28000 | - |
about | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
hydroxymethylbilane | Homo sapiens | macrocyclic, role of the enzyme in tetrapyrrole based copound biosynthesis, overview | uroporphyrinogen-III + H2O | - |
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Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
hydroxymethylbilane = uroporphyrinogen III + H2O | in the presence of hydroxymethylbilane synthase EC 4.3.1.8, enzyme forms uroporphyrinogen III from porphobilinogen, reaction mechanism, does not require acid/base catalysis, active site structure | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
hydroxymethylbilane | linear tetrapyrrole | Homo sapiens | uroporphyrinogen-III + H2O | - |
? | |
hydroxymethylbilane | macrocyclic, role of the enzyme in tetrapyrrole based copound biosynthesis, overview | Homo sapiens | uroporphyrinogen-III + H2O | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | enzyme structure, model | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
U3S | - |
Homo sapiens |
Uroporphyrinogen III synthase | - |
Homo sapiens |