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Literature summary for 4.2.1.70 extracted from

  • Chaudhuri, B.N.; Chan, S.; Perry, L.J.; Yeates, T.O.
    Crystal structure of the apo forms of psi55 tRNA pseudouridine synthase from Mycobacterium tuberculosis. A hinge at the base of the catalytic cleft (2004), J. Biol. Chem., 279, 24585-24591.
    View publication on PubMed
Search for more literature for 4.2.1.70

Cloned(Commentary)

Cloned (Comment) Organism
Rv2793c gene, expression in Escherichia coli Mycobacterium tuberculosis

Crystallization (Commentary)

Crystallization (Comment) Organism
TruB, two substrate-free forms, sitting-drop vapor-diffusion method Mycobacterium tuberculosis

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble recombinant TruB Mycobacterium tuberculosis
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
uridinyl-tRNA Mycobacterium tuberculosis TruB is specific for the nearly universal psi55 in tRNA pseudouridinyl-tRNA
-
 ?
uridinyl-tRNA Mycobacterium tuberculosis TruB TruB is specific for the nearly universal psi55 in tRNA pseudouridinyl-tRNA
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
 TruB
-
Mycobacterium tuberculosis TruB
-
 TruB
-

Purification (Commentary)

Purification (Comment) Organism
recombinant TruB Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
uridinyl-tRNA TruB is specific for the nearly universal psi55 in tRNA, mechanism of tRNA recognition, protein dynamics, base flipping and modification play a role in tRNA recognition, TruB structure, 2 domains: the large N-terminal catalytic domain and the short C-terminal RNA-binding domain Mycobacterium tuberculosis pseudouridinyl-tRNA
-
 ?
uridinyl-tRNA TruB is specific for the nearly universal psi55 in tRNA Mycobacterium tuberculosis pseudouridinyl-tRNA
-
 ?
uridinyl-tRNA TruB is specific for the nearly universal psi55 in tRNA, mechanism of tRNA recognition, protein dynamics, base flipping and modification play a role in tRNA recognition, TruB structure, 2 domains: the large N-terminal catalytic domain and the short C-terminal RNA-binding domain Mycobacterium tuberculosis TruB pseudouridinyl-tRNA
-
 ?
uridinyl-tRNA TruB is specific for the nearly universal psi55 in tRNA Mycobacterium tuberculosis TruB pseudouridinyl-tRNA
-
 ?

Synonyms

Synonyms Comment Organism
More pseudouridine synthases are classified into the sequence families TruB, TruA, RsuA, RluA and TruD Mycobacterium tuberculosis
psi55 tRNA pseudouridine synthase
-
 Mycobacterium tuberculosis
PUS
-
 Mycobacterium tuberculosis
TruB
-
 Mycobacterium tuberculosis