Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.2.1.51 extracted from

  • Tan, K.; Li, H.; Zhang, R.; Gu, M.; Clancy, S.T.; Joachimiak, A.
    Structures of open (R) and close (T) states of prephenate dehydratase (PDT)-implication of allosteric regulation by L-phenylalanine (2007), J. Struct. Biol., 162, 94-107.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structures of prephenate dehydratase in a relaxed (R) state Staphylococcus aureus
crystal structures of prephenate dehydratase in a tense (T) state Chlorobaculum tepidum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
prephenate Staphylococcus aureus converts prephenate to phenylpyruvate in L-phenylalanine biosynthesis phenylpyruvate + H2O + CO2
-
?
prephenate Chlorobaculum tepidum converts prephenate to phenylpyruvate in L-phenylalanine biosynthesis phenylpyruvate + H2O + CO2
-
?

Organism

Organism UniProt Comment Textmining
Chlorobaculum tepidum
-
-
-
Staphylococcus aureus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
prephenate converts prephenate to phenylpyruvate in L-phenylalanine biosynthesis Staphylococcus aureus phenylpyruvate + H2O + CO2
-
?
prephenate converts prephenate to phenylpyruvate in L-phenylalanine biosynthesis Chlorobaculum tepidum phenylpyruvate + H2O + CO2
-
?
prephenate at the interface two ACT regulatory domains create two highly conserved pockets. Upon binding of the L-Phe inside the pockets, PDT transits from an open to a closed conformation Staphylococcus aureus phenylpyruvate + H2O + CO2
-
?
prephenate at the interface two ACT regulatory domains create two highly conserved pockets. Upon binding of the L-Phe inside the pockets, PDT transits from an open to a closed conformation Chlorobaculum tepidum phenylpyruvate + H2O + CO2
-
?

Subunits

Subunits Comment Organism
tetramer
-
Staphylococcus aureus
tetramer in crystal and solution Chlorobaculum tepidum

Synonyms

Synonyms Comment Organism
Sa-PDT
-
Staphylococcus aureus
Ct-PDT
-
Chlorobaculum tepidum