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Literature summary for 4.2.1.51 extracted from
- Structures of open (R) and close (T) states of prephenate dehydratase (PDT)-implication of allosteric regulation by L-phenylalanine (2007), J. Struct. Biol., 162, 94-107.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| crystal structures of prephenate dehydratase in a relaxed (R) state | Staphylococcus aureus |
| crystal structures of prephenate dehydratase in a tense (T) state | Chlorobaculum tepidum |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| prephenate | Staphylococcus aureus | converts prephenate to phenylpyruvate in L-phenylalanine biosynthesis | phenylpyruvate + H2O + CO2 | - |
? |  |
| prephenate | Chlorobaculum tepidum | converts prephenate to phenylpyruvate in L-phenylalanine biosynthesis | phenylpyruvate + H2O + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Chlorobaculum tepidum | - |
- |
- |
| Staphylococcus aureus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| prephenate | converts prephenate to phenylpyruvate in L-phenylalanine biosynthesis | Staphylococcus aureus | phenylpyruvate + H2O + CO2 | - |
? | |
| prephenate | converts prephenate to phenylpyruvate in L-phenylalanine biosynthesis | Chlorobaculum tepidum | phenylpyruvate + H2O + CO2 | - |
? | |
| prephenate | at the interface two ACT regulatory domains create two highly conserved pockets. Upon binding of the L-Phe inside the pockets, PDT transits from an open to a closed conformation | Staphylococcus aureus | phenylpyruvate + H2O + CO2 | - |
? | |
| prephenate | at the interface two ACT regulatory domains create two highly conserved pockets. Upon binding of the L-Phe inside the pockets, PDT transits from an open to a closed conformation | Chlorobaculum tepidum | phenylpyruvate + H2O + CO2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | - |
Staphylococcus aureus |
| tetramer | in crystal and solution | Chlorobaculum tepidum |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Ct-PDT | - |
Chlorobaculum tepidum |
| Sa-PDT | - |
Staphylococcus aureus |
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Release 2023.1 (January 2023)
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