Literature summary for 4.2.1.47 extracted from

Matsuo, K.; Matsumura, T.
Deletion of fucose residues in plant N-glycans by repression of the GDP-mannose 4,6-dehydratase gene using virus-induced gene silencing and RNA interference (2011), Plant Biotechnol. J., 9, 264-281.

Search for more literature for 4.2.1.47

Application

Application	Comment	Organism
biotechnology	repression of the GMD gene is thus very useful for deleting immunogenic total fucose residues and facilitating the production of pharmaceutical glycoproteins in plants	Nicotiana benthamiana
synthesis	repression of the GMD gene is thus very useful for deleting immunogenic total fucose residues and facilitating the production of pharmaceutical glycoproteins in plants	Nicotiana benthamiana

Cloned(Commentary)

Cloned (Comment)	Organism
GMD DNA and amino acid sequence determination and analysis	Nicotiana benthamiana

Protein Variants

Protein Variants	Comment	Organism
additional information	deletion of alpha-1,3-fucose and alpha-1,4-fucose residues in Nicotiana benthamiana plants N-glycans by repression of the GMD gene using virus-induced gene silencing and RNA interference, GMD expression analysis, and MALDI-TOF-mass spectrometric analysis of N-glycans in wild-type and mutant plants, overview	Nicotiana benthamiana

Organism

Organism	UniProt	Comment	Textmining
Nicotiana benthamiana	B7XH28	-	-

Synonyms

Synonyms	Comment	Organism
GMD	-	Nicotiana benthamiana
guanosine 5'-diphosphate-D-mannose 4,6-dehydratase	-	Nicotiana benthamiana

General Information

General Information	Comment	Organism
metabolism	the first step of the de novo pathway starting from GDP-D-mannose is a dehydration reaction catalysed by the specific nucleotide-sugar dehydratase GMD resulting in GDP-L-fucose synthesis	Nicotiana benthamiana

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Release 2023.1 (January 2023)