Literature summary for 4.2.1.47 extracted from

Webb, N.A.; Mulichak, A.M.; Lam, J.S.; Rocchetta, H.L.; Garavito, R.M.
Crystal structure of a tetrameric GDP-D-mannose 4,6-dehydratase from a bacterial GDP-D-rhamnose biosynthetic pathway (2004), Protein Sci., 13, 529-539.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
complexed with NADPH and GDP, hanging drop vapor diffusion method	Pseudomonas aeruginosa

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas aeruginosa	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O	mechanism	Pseudomonas aeruginosa	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GDP-mannose	-	Pseudomonas aeruginosa	GDP-4-dehydro-6-deoxy-D-mannose + H2O	-	?

Subunits

Subunits	Comment	Organism
tetramer	homotetramer, crystallization experiments	Pseudomonas aeruginosa

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Pseudomonas aeruginosa

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Release 2023.1 (January 2023)