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Literature summary for 4.2.1.46 extracted from

  • Zarkowsky, H.; Lipkin, E.; Glaser, L.
    The mechanism of 6-deoxyhexose synthesis. V. The relation of pyridine nucleotide to the structure of the deoxythymidine diphosphate-glucose oxidoreductase (1970), J. Biol. Chem., 245, 6599-6606.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
dTDP-6-deoxy-D-glucose
-
 Escherichia coli
p-hydroxymercuribenzoate
-
 Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
 2 * 40000, gel filtration Escherichia coli
78000
-
 gel filtration Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dTDP-glucose Escherichia coli
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dTDP-glucose
-
 Escherichia coli dTDP-4-dehydro-6-deoxy-D-glucose + H2O
-
 ?
dTDP-glucose
-
 Escherichia coli ?
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 40000, gel filtration Escherichia coli

Cofactor

Cofactor Comment Organism Structure
NAD+ 1 mol of bound NAD+ per mol of enzyme Escherichia coli
NAD+ role of NAD+ in catalysis Escherichia coli