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Literature summary for 4.2.1.45 extracted from

  • Hallis, R.M.; Liu, H.
    Stereospecificity of hydride transfer for the catalytically recycled NAD+ in CDP-D-glucose 4,6-dehdratase (1998), Tetrahedron, 54, 15975-15982.
No PubMed abstract available

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CDP-glucose Yersinia pseudotuberculosis biosynthetic pathway of 3,6-dideoxysugars ?
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Organism

Organism UniProt Comment Textmining
Yersinia pseudotuberculosis
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Pasteurella pseudotuberculosis
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Reaction

Reaction Comment Organism Reaction ID
CDP-glucose = CDP-4-dehydro-6-deoxy-D-glucose + H2O stereochemistry, intramolecular oxidation-reduction that involves an internal hydrogen transfer from C-4 of the substrate to C-6 of the resulting product Yersinia pseudotuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CDP-D-glucose
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Yersinia pseudotuberculosis CDP-4-dehydro-6-deoxy-D-glucose + H2O CDP-6-deoxy-D-glycero-L-threo-4-hexulose ?
CDP-glucose biosynthetic pathway of 3,6-dideoxysugars Yersinia pseudotuberculosis ?
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?

Cofactor

Cofactor Comment Organism Structure
NAD+ catalytic prosthetic group, NAD+ serves as a hydride carrier receiving the 4H of the substrate in the oxidative half-reaction and passing the reducing equivalents to C-6 in the reductive half-reaction, the substrate is bound to the si-face of the nicotinamide ring Yersinia pseudotuberculosis