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Literature summary for 4.2.1.36 extracted from
- The Aspergillus nidulans lysF gene encodes homoaconitase, an enzyme involved in the fungus-specific lysine pathway (1997), Mol. Gen. Genet., 255, 237-247.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Aspergillus nidulans |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.1 | - |
2-hydroxy-3-carboxyadipate | - |
Aspergillus nidulans |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-Hydroxy-3-carboxyadipate | Aspergillus nidulans | enzyme is involved in the L-Lys biosynthesis via 2-aminoadipate pathway | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Aspergillus nidulans | - |
i.e. Aspergillus nidulans, the mutant strain LysF88 has drastically reduced homoaconitase activity relative to the wild-type strain | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-Hydroxy-3-carboxyadipate | enzyme is involved in the L-Lys biosynthesis via 2-aminoadipate pathway | Aspergillus nidulans | ? | - |
? | |
| 2-hydroxybutane-1,2,4-tricarboxylate | - |
Aspergillus nidulans | but-1-ene-1,2,4-tricarboxylate + H2O | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.1 | 8.6 | potassium phosphate buffer | Aspergillus nidulans |
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Release 2023.1 (January 2023)
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