Protein Variants | Comment | Organism |
---|---|---|
C459S | catalytically inactive mutant without its [4Fe-4S]-cluster. Mitochondrial morphological defects as a consequence of acon inactivation depend on its [4Fe-4S] cluster | Drosophila melanogaster |
S677A | catalytically inactive mutant | Drosophila melanogaster |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Drosophila melanogaster | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
[4Fe-4S] center | acon harbors a single unligated iron atom in its [4Fe-4S], enzyme is in this respect unique in mitochondria | Drosophila melanogaster |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
acon | - |
Drosophila melanogaster |
aconitase | - |
Drosophila melanogaster |
General Information | Comment | Organism |
---|---|---|
malfunction | aconitase down-regulation suppresses pink1 mutant phenotypes. In contrast to partial loss of aconitase that rescues mitochondrial defects in pink1 mutants, overexpression of aconitase in transgenic mice causes mitochondrial morphological defects and swelling of mitochondria in dopaminergic neurons | Drosophila melanogaster |