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Literature summary for 4.2.1.3 extracted from

  • Pechter, K.B.; Meyer, F.M.; Serio, A.W.; Stuelke, J.; Sonenshein, A.L.
    Two roles for aconitase in the regulation of tricarboxylic acid branch gene expression in Bacillus subtilis (2013), J. Bacteriol., 195, 1525-1537.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
C450S mutant is enzymatically inactive, glutamate auxotroph and accumulates citrate. Mutant strain exhibits overexpression of the citB promoter and accumulates high levels of aconitase protein. Mutant strain exhibits increased levels of citrate synthase protein. Mutant enzyme does not bind to the citrate synthase 5' leader RNA in vitro Bacillus subtilis
R741E mutant is designed to be defective in RNA binding. Mutant strain is glutamate prototroph and accumulates citrate. Mutant strain exhibits overexpression of the citB promoter and accumulates high levels of aconitase protein. Mutant strain exhibits increased levels of citrate synthase protein. Mutant enzyme does not bind to the citrate synthase 5' leader RNA in vitro Bacillus subtilis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Bacillus subtilis aconitase binds bound to the citrate synthase 5' leader RNA in vitro ?
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?

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
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-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information aconitase binds bound to the citrate synthase 5' leader RNA in vitro Bacillus subtilis ?
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?

Synonyms

Synonyms Comment Organism
aconitase
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Bacillus subtilis
citB
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Bacillus subtilis

General Information

General Information Comment Organism
physiological function aconitase directly regulates citrate synthase production by interacting with the citZ transcript Bacillus subtilis