Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Fluorocitrate | active site aconitase inhibitor blocks erythroid differentiation in a manner similar to iron deprivation; active site aconitase inhibitor blocks erythroid differentiation in a manner similar to iron deprivation | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
mitochondrion | - |
Homo sapiens | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe | iron restriction reproducibly causes 60% decreases in both mitochondrial and cytosolic aconitase activities in erythroid samples | Homo sapiens | |
Fe2+ | iron restriction reproducibly causes 60% decreases in both mitochondrial and cytosolic aconitase activities in erythroid samples | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P21399 | - |
- |
Homo sapiens | Q99798 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
PBMC cell | purified human CD34+ progenitors derived from granulocyte-colony stimulating factor mobilized peripheral blood cells of normal donors | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
Aco1 | cytosolic aconitase | Homo sapiens |
Aco2 | mitochondrial aconitase | Homo sapiens |
aconitase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | iron restriction suppresses mitochondrial and cytosolic aconitase activity in erythroid but not granulocytic or megakaryocytic progenitors. The mechanism for aconitase regulation of erythropoiesis most likely involves both production of metabolic intermediates as well as modulation of erythropoietin signaling | Homo sapiens |