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Literature summary for 4.2.1.3 extracted from

  • Cherkasov, A.A.; Overton, R.A.; Sokolov, E.P.; Sokolova, I.M.
    Temperature-dependent effects of cadmium and purine nucleotides on mitochondrial aconitase from a marine ectotherm, Crassostrea virginica: a role of temperature in oxidative stress and allosteric enzyme regulation (2007), J. Exp. Biol., 210, 46-55.
    View publication on PubMed

Application

Application Comment Organism
environmental protection use of enzyme as biomarker of oxidative damage. Exposure of oysters to Cd2+ results in elevated production of reactive oxygen species and enzyme inhibition, which is particualrly pronounced at elevated temperature Crassostrea virginica

Inhibitors

Inhibitors Comment Organism Structure
ADP inhibition at levels well above its physiological concentration Crassostrea virginica
ATP
-
Crassostrea virginica
Cd2+ inactivation of enzyme, particularly at elevated temperature Crassostrea virginica
GDP inhibition at levels well above its physiological concentration Crassostrea virginica

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Crassostrea virginica 5739
-

Organism

Organism UniProt Comment Textmining
Crassostrea virginica
-
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.93
-
20°C Crassostrea virginica ATP
3.04
-
30°C Crassostrea virginica ATP
3.04
-
30°C Crassostrea virginica GDP
5.63
-
20°C Crassostrea virginica ADP
6.53
-
20°C Crassostrea virginica GDP
6.88
-
30°C Crassostrea virginica ADP