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Literature summary for 4.2.1.24 extracted from
- Optimization of the heme biosynthesis pathway for the production of 5-aminolevulinic acid in Escherichia coli (2015), Sci. Rep., 5, 8584 .
Application
| Application | Comment | Organism |
|---|---|---|
| synthesis | in addition to hemA and hemL, hemB, hemD, hemF, hemG and hemH are also major regulatory targets of the heme biosynthesis pathway. Up-regulation of hemD and hemF benefits ALA accumulation whereas overexpression of hemB, hemG and hemH diminishes ALA accumulation. By combinatorial overexpression of hemA, hemL,hemD and hemF with different copy-number plasmids, the titer of ALA can be improved to 3.25 g/l | Escherichia coli |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| protoporphyrinogen IX | feedback inhibition by downstream intermediate | Escherichia coli |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HemB | - |
Escherichia coli |
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Release 2023.1 (January 2023)
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