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Literature summary for 4.2.1.24 extracted from

  • Franca, R.T.; DA Silva, A.S.; Wolkmer, P.; Oliveira, V.A.; Pereira, M.E.; Leal, M.L.; Silva, C.B.; Nunes, M.A.; Dressler, V.L.; Mazzanti, C.M.; Monteiro, S.G.; Lopes, S.T.
    delta-Aminolevulinate dehydratase activity in red blood cells of rats infected with Trypanosoma evansi (2011), Parasitology, 138, 1272-1277.
    View publication on PubMed
Search for more literature for 4.2.1.24

Inhibitors

Inhibitors Comment Organism Structure
additional information in vivo iron reduction in rat blood has a negative correlation with the activity of delta-ALA-D, overview Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ delta-ALA-D is a metalloenzyme requiring zinc for activation Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 5-aminolevulinate Rattus norvegicus
-
 porphobilinogen + 2 H2O
-
 ?
2 5-aminolevulinate Rattus norvegicus Wistar
-
 porphobilinogen + 2 H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 animals infected with Trypanosoma evansi
-
Rattus norvegicus Wistar
-
 animals infected with Trypanosoma evansi
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 5-aminolevulinate
-
 Rattus norvegicus porphobilinogen + 2 H2O
-
 ?
2 5-aminolevulinate
-
 Rattus norvegicus Wistar porphobilinogen + 2 H2O
-
 ?

Synonyms

Synonyms Comment Organism
delta-ALA-D
-
 Rattus norvegicus
delta-aminolevulinate dehydratase
-
 Rattus norvegicus
PBG-synthase
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
39
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
 assay at Rattus norvegicus

General Information

General Information Comment Organism
physiological function infection with Trypanosoma evansi is associated with haematocrit, serum levels of iron and zinc and lipid peroxidation. Increased activity of delta-ALA-D in blood occurs in response to the anaemia in remission as heme synthesis is enhanced, iron reduction has a negative correlation with the activity of delta-ALA-D Rattus norvegicus