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Literature summary for 4.2.1.24 extracted from

  • Coates, L.; Beaven, G.; Erskine, P.T.; Beale, S.I.; Wood, S.P.; Shoolingin-Jordan, P.M.; Cooper, J.B.
    Structure of Chlorobium vibrioforme 5-aminolaevulinic acid dehydratase complexed with a diacid inhibitor (2005), Acta Crystallogr. Sect. D, 61, 1594-1598.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
structure of 5-aminolaevulinic acid dehydratase complexed with the irreversible inhibitor 4,7-dioxosebacic acid Prosthecochloris vibrioformis

Inhibitors

Inhibitors Comment Organism Structure
4,7-dioxosebacic acid hanging-drop method, irreversible inhibitor binds by forming Schiff-base linkages with lysines 200 and 253 at the active site. 4,7-dioxosebacic acid is a better inhibitor of the zinc-dependent 5-aminolaevulinic acid dehydratases than of the zinc-independent 5-aminolaevulinic acid dehydratases Prosthecochloris vibrioformis

Organism

Organism UniProt Comment Textmining
Prosthecochloris vibrioformis
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