Literature summary for 4.2.1.24 extracted from

Bolzan, R.C.; Folmer, V.; Farina, M.; Zeni, G.; Nogueira, C.W.; Rocha, J.B.; Emanuelli, T.
delta-Aminolevulinate dehydratase inhibition by phenyl selenoacetylene: effect of reaction with hydrogen peroxide (2002), Pharmacol. Toxicol., 90, 214-219.

Search for more literature for 4.2.1.24

Inhibitors

Inhibitors	Comment	Organism	Structure
phenyl selenoacetylene	IC50: above 0.4 mM	Cucumis sativus
phenyl selenoacetylene	IC50: 0.25 mM	Rattus norvegicus
phenyl selenoxideacetylene	IC50: 0.1 mM, inhibition is antagonized by dithiothreitol	Cucumis sativus
phenyl selenoxideacetylene	IC50: 0.045 mM, inhibition is antagonized by dithiothreitol	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Cucumis sativus	-	-	-
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
leaf	-	Cucumis sativus	-
liver	-	Rattus norvegicus	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.045	-	IC50: 0.045 mM, inhibition is antagonized by dithiothreitol	Rattus norvegicus	phenyl selenoxideacetylene
0.1	-	IC50: 0.1 mM, inhibition is antagonized by dithiothreitol	Cucumis sativus	phenyl selenoxideacetylene
0.25	-	IC50: 0.25 mM	Rattus norvegicus	phenyl selenoacetylene
0.4	-	IC50: above 0.4 mM	Cucumis sativus	phenyl selenoacetylene

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Release 2023.1 (January 2023)