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Literature summary for 4.2.1.24 extracted from

  • Gibbs, P.N.B.; Chaudhry, A.G.; Jordan, P.M.
    Purification and properties of 5-aminolevulinate dehydratase from human erythrocytes (1985), Biochem. J., 230, 25-34.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.2.1.24

Inhibitors

Inhibitors Comment Organism Structure
5,5'-dithiobis(2-nitrobenzoic acid)
-
 Homo sapiens
EDTA
-
 Homo sapiens
Pb2+ noncompetitive Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.287
-
 5-aminolevulinate
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ required Homo sapiens
Zn2+ optimal activation by 0.1-0.3 mM ZnCl2 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
 8 * 35000, SDS-PAGE Homo sapiens
285000
-
 gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Oxidation Stability

Oxidation Stability Organism
sensitive to oxygen, t1/2: 135 min, the oxygen-inactivated enzyme is restored to full activity by incubation with thiols Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.4
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-aminolevulinate + 5-aminolevulinate
-
 Homo sapiens porphobilinogen + 2 H2O
-
 ?

Subunits

Subunits Comment Organism
octamer 8 * 35000, SDS-PAGE Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
-
 Homo sapiens