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Literature summary for 4.2.1.22 extracted from

  • Nandi, S.; Mishra, P.
    H2S and homocysteine control a novel feedback regulation of cystathionine beta synthase and cystathionine gamma lyase in cardiomyocytes (2017), Sci. Rep., 7, 3639 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine treatment with homocysteine upregulates cystathionine gamma lyase CSE but downregulates CBS whereas Na2S or H2S-donoer GYY4137 downregulates CSE but upregulates CBS in a dose-dependent manner. In the homocysteine-treated cardiomyocytes, CBS and miR-133a are downregulated and hypertrophy is inducedIn vivo studies using CBS+/- mice, a model for hyperhomocysteinemia, and sibling CBS+/+ control mice revealed that deficiency of CBS upregulates cardiac CSE Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
cardiomyocyte cell line
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 Mus musculus
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HL-1 cell
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 Mus musculus
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Expression

Organism Comment Expression
Mus musculus treatment with homocysteine upregulates cystathionine gamma lyase CSE but downregulates CBS whereas Na2S or H2S-donoer GYY4137 downregulates CSE but upregulates CBS in a dose-dependent manner. In the homocysteine-treated cardiomyocytes, CBS and miR-133a are downregulated and hypertrophy is induced additional information