Literature summary for 4.2.1.22 extracted from

Vicente, J.B.; Colaco, H.G.; Sarti, P.; Leandro, P.; Giuffre, A.
S-Adenosyl-L-methionine modulates CO and NO* binding to the human H2S-generating enzyme cystathionine beta-synthase (2016), J. Biol. Chem., 291, 572-581 .

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Activating Compound

Activating Compound	Comment	Organism	Structure
S-adenosyl-L-methionine	AdoMet binding significantly enhances CBS inhibition by CO. NO radical binding to reduced CBS i also enhanced by AdoMet, although to a lesser as compared with CO. CO and NOradical binding is unchanged by AdoMet in a truncated form of CBS lacking the C-terminal regulatory domain	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P35520	-	-

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Release 2023.1 (January 2023)