Application | Comment | Organism |
---|---|---|
medicine | breast cancer patient-derived tissues and breast cancer cells exhibit significantly increased levels of CBS when compared with their normal counterparts, associated with increased levels of H2S and cystathionine. Silencing of CBS in breast cancer cells causes a significant decrease in the levels of H2S and cystathionine but does not affect the growth of these cells per se, in in vitro cultures. CBS-silenced cells exhibit significantly reduced growth in the presence of activated macrophages and in xenograft models, associated with an increase in the steady state levels of reactive aldehyde-derived protein adducts | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hs-578T cell | - |
Homo sapiens | - |
MCF-10A cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
MDA-MB-468 cell | - |
Homo sapiens | - |