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Literature summary for 4.2.1.22 extracted from

  • Albertini, E.; Koziel, R.; Duerr, A.; Neuhaus, M.; Jansen-Duerr, P.
    Cystathionine beta synthase modulates senescence of human endothelial cells (2012), Aging, 4, 664-673.
    View publication on PubMedView publication on EuropePMC
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Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
65000
-
 x * 65000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-serine + L-homocysteine Homo sapiens
-
 L-cystathionine + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell
-
 Homo sapiens
-
HUVEC cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-serine + L-homocysteine
-
 Homo sapiens L-cystathionine + H2O
-
 ?

Subunits

Subunits Comment Organism
? x * 65000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
CBS
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction depletion of cystathionine beta synthase induces premature senescence in human endothelial cells, induces mild mitochondrial dysfunction and increases the sensitivity of endothelial cells to homocysteine, a known inducer of endothelial cell senescence and an established risk factor for vascular disease Homo sapiens
physiological function enzyme overexpression extends lifespan of human endothelial cells Homo sapiens