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Literature summary for 4.2.1.22 extracted from

  • Jensen, K.K.; Geoghagen, N.S.; Jin, L.; Holt, T.G.; Luo, Q.; Malkowitz, L.; Ni, W.; Quan, S.; Waters, M.G.; Zhang, A.; Zhou, H.H.; Cheng, K.; Luo, M.J.
    Pharmacological activation and genetic manipulation of cystathionine beta-synthase alter circulating levels of homocysteine and hydrogen sulfide in mice (2011), Eur. J. Pharmacol., 650, 86-93.
    View publication on PubMed
Search for more literature for 4.2.1.22

Activating Compound

Activating Compound Comment Organism Structure
Ethionine i.e. 2-amino-4-(ethylthio)butyric acid, an methionine analogue, which is converted to S-adenosyl-ethionine in vivo and activates CBS, treatment increased liver CBS activity 4.0fold in wild-type mice Mus musculus
S-adenosyl-L-methionine
-
 Mus musculus
S-adenosyl-L-methionine
-
 Rattus norvegicus
S-adenosyl-L-methionine activates CBS by 13.6fold in Hep-G2 cell lysate Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information CBS activity in liver homogenates is reduced and plasma homocysteine levels are elevated in the CBS heterozygous knockout , CBS-/+ animals compared to wild-type littermate control mice. H2S is also significantly reduced by 30% and 46% compared to wild type in male and female CBS-/+ animals respectively Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-serine + L-homocysteine Mus musculus
-
 L-cystathionine + H2O
-
 ?
L-serine + L-homocysteine Homo sapiens
-
 L-cystathionine + H2O
-
 ?
L-serine + L-homocysteine Rattus norvegicus
-
 L-cystathionine + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-
liver
-
 Mus musculus
-
liver
-
 Homo sapiens
-
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-serine + L-homocysteine
-
 Mus musculus L-cystathionine + H2O
-
 ?
L-serine + L-homocysteine
-
 Homo sapiens L-cystathionine + H2O
-
 ?
L-serine + L-homocysteine
-
 Rattus norvegicus L-cystathionine + H2O
-
 ?
additional information CBS also catalyze H2S production in vitro Mus musculus ?
-
 ?
additional information CBS also catalyze H2S production in vitro Homo sapiens ?
-
 ?
additional information CBS also catalyze H2S production in vitro Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
CBS
-
 Mus musculus
CBS
-
 Homo sapiens
CBS
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus
37
-
 assay at Homo sapiens
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
 assay at Mus musculus
8.5
-
 assay at Homo sapiens
8.5
-
 assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Mus musculus
pyridoxal 5'-phosphate
-
 Homo sapiens
pyridoxal 5'-phosphate
-
 Rattus norvegicus

General Information

General Information Comment Organism
additional information increased immunoreactivity is evident in liver homogenates from mice treated with adenovirus carrying human CBS compared to mice treated with the Ad-lacZ virus Homo sapiens
additional information increased immunoreactivity is evident in liver homogenates from mice treated with adenovirus carrying human CBS compared to mice treated with the Ad-lacZ virus. Overexpression of hCBS reduces homocysteine levels significantly by 5.3fold compared to Ad-lacZ treated mice Mus musculus
physiological function CBS activity partially regulates endogenous H2S in mice. It contributes significantly to endogenous H2S production in mice, adenovirus-mediated overexpression of CBS in the liver significantly increases circulating levels of H2S, whereas CBS deficiency results in reduced levels. irculating H2S levels are increased by pharmacological activation of CBS in vivo; i.e. in the presence of the endogenous activator Mus musculus