Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | treatment with 0.2 M trimethylamine-N-oxide results in rescuing expression as well as activity of CBS to 82% of human wild type CBS produced in a yeast heme-deficient strain | Homo sapiens | |
S-adenosyl-L-methionine | allosteric activation | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in heme-deficient strains of Saccharomyces cerevisiae and Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Co3+ | Co3+ has 30-60% of the specific activity of Fe3+-CBS | Homo sapiens | |
Mn3+ | Mn3+ has 30-60% of the specific activity of Fe3+-CBS | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
glutathione-Sepharose column chromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-serine + L-homocysteine | - |
Homo sapiens | L-cystathionine + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CBS | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | requires a heme cofactor for maximal activity, heme plays a key role in proper CBS folding and assembly | Homo sapiens | |
pyridoxal 5'-phosphate | dependent on | Homo sapiens |