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Literature summary for 4.2.1.22 extracted from

  • Shintani, T.; Iwabuchi, T.; Soga, T.; Kato, Y.; Yamamoto, T.; Takano, N.; Hishiki, T.; Ueno, Y.; Ikeda, S.; Sakuragawa, T.; Ishikawa, K.; Goda, N.; Kitagawa, Y.; Kajimura, M.; Matsumoto, K.; Suematsu, M.
    Cystathionine beta-synthase as a carbon monoxide-sensitive regulator of bile excretion (2009), Hepatology, 49, 141-150.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
carbon monoxide binds to the prosthetic heme, stabilizing 6-coordinated CO-Fe(II)-histidine complex to block the activity Mus musculus
carbon monoxide binds to the prosthetic heme, stabilizing 6-coordinated CO-Fe(II)-histidine complex to block the activity Rattus norvegicus
additional information not inhibited by nitric oxide Mus musculus
additional information not inhibited by nitric oxide Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cysteine + ?
-
Mus musculus H2S + ?
-
?
cysteine + ?
-
Rattus norvegicus H2S + ?
-
?
L-serine + L-homocysteine
-
Mus musculus L-cystathionine + H2O
-
?
L-serine + L-homocysteine
-
Rattus norvegicus L-cystathionine + H2O
-
?

Synonyms

Synonyms Comment Organism
CBS
-
Mus musculus
CBS
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
heme
-
Mus musculus
heme
-
Rattus norvegicus
pyridoxal 5'-phosphate
-
Mus musculus
pyridoxal 5'-phosphate
-
Rattus norvegicus