Literature summary for 4.2.1.22 extracted from

Kabil, O.; Zhou, Y.; Banerjee, R.
Human cystathionine beta-synthase is a target for sumoylation (2006), Biochemistry, 45, 13528-13536.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	sumoylated CBS is present in the nucleus where it is associated with the nuclear scaffold	Homo sapiens	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
sumoylation	CBS is modified by the small ubiquitin-like modifier-1 protein (SUMO-I) under both in vitro and in vivo conditions. Deletion analysis of CBS indicates that the C-terminal regulatory domain is required for interaction with proteins in the sumoylation machinery. Sumoylated CBS is present in the nucleus where it is associated with the nuclear scaffold	Homo sapiens

Synonyms

Synonyms	Comment	Organism
cystathionine beta-synthase	-	Homo sapiens

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Release 2023.1 (January 2023)