Literature summary for 4.2.1.22 extracted from

Frank, N.; Kery, V.; Maclean, K.N.; Kraus, J.P.
Solvent-accessible cysteines in human cystathionine beta-synthase: crucial role of cysteine 431 in S-adenosyl-L-methionine binding (2006), Biochemistry, 45, 11021-11029.

Search for more literature for 4.2.1.22

Activating Compound

Activating Compound	Comment	Organism	Structure
S-adenosyl-L-methionine	activates	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
C15S	mutagenesis does not affect catalysis or S-adenosyl-L-methionine activation but significantly reduces aggregation of the purified enzyme in vitro	Homo sapiens
C431S	mutagenesis results in a constitutively activated form of CBS that can not be further activated by either S-adenosyl-L-methionine or thermal activation	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-Serine + homocysteine	-	Homo sapiens	Cystathionine + H2O	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)