Literature summary for 4.2.1.22 extracted from

Oliveriusova, J.; Kery, V.; Maclean, K.N.; Kraus, J.P.
Deletion mutagenesis of human cystathionine beta-synthase. Impact on activity, oligomeric status, and S-adenosylmethionine regulation (2002), J. Biol. Chem., 277, 48386-48394.

Search for more literature for 4.2.1.22

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	deletion of 70 N-terminal residues results in a heme-free protein retaining 20% activity, additional deletion of 151 C-terminal residues results in an inactive enzyme, deletion of 8 C-terminal residues results in increased enzyme activity and abolishes any further activation by S-adenosyl-L-methionine	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
full length enzyme exhibits a strong tendency toward aggregation during the course of purification as well as in the purified state	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-Serine + homocysteine	-	Homo sapiens	Cystathionine + H2O	-	r

Subunits

Subunits	Comment	Organism
tetramer	SDS-PAGE	Homo sapiens

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Release 2023.1 (January 2023)