Literature summary for 4.2.1.22 extracted from

Jhee, K.H.; Niks, D.; McPhie, P.; Dunn, M.F.; Miles, E.W.
The reaction of yeast cystathionine beta-synthase is rate-limited by the conversion of aminoacrylate to cystathionine (2001), Biochemistry, 40, 10873-10880.

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Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
L-serine + L-homocysteine = L-cystathionine + H2O	mechanism	Saccharomyces cerevisiae	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-Serine + homocysteine	-	Saccharomyces cerevisiae	Cystathionine + H2O	-	r

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	forms a series of intermediates during the reaction, gem-diamine and external aldimine of aminoacrylate are the primary intermediates in the forward half-reaction with L-serine and the external aldimine of aminoacrylate or its complex with L-homocysteine is the primary intermediate in the reverse half-reaction with L-cystathionine	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)