Crystallization (Comment) | Organism |
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structures of tryptophan synthase crystallized with varying numbers of amphipathic N-(4'-trifluoromethoxybenzoyl)-2-aminoethyl phosphate. One of the ligands threads into the tunnel from the beta-site and reveals a distinct hydrophobic region. The N-(4'-trifluoromethoxybenzoyl)-2-aminoethyl phosphate phosphoryl group fits into a polar pocket of the beta-subunit active site. One portion of the tunnel binds clusters of water molecules, whereas waters are not observed in the nonpolar N-(4'-trifluoromethoxybenzoyl)-2-aminoethyl phosphate binding region of the tunnel. Hydrophobic molecules can freely diffuse between the alpha- and beta-sites via the tunnel, while water does not. Exclusion of water may serve to inhibit reaction of water with the alpha-aminoacrylate intermediate to form ammonium ion and pyruvate | Salmonella enterica subsp. enterica serovar Typhimurium |
Inhibitors | Comment | Organism | Structure |
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N-(4'-trifluoromethoxybenzoyl)-2-aminoethyl phosphate | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
Organism | UniProt | Comment | Textmining |
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Salmonella enterica subsp. enterica serovar Typhimurium | P00929 | - |
- |
Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 | P00929 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
TrpA | alpha-subinit | Salmonella enterica subsp. enterica serovar Typhimurium |