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Literature summary for 4.2.1.20 extracted from

  • Phillips, R.S.; McPhie, P.; Miles, E.W.; Marchal, S.; Lange, R.
    Quantitative effects of allosteric ligands and mutations on conformational equilibria in Salmonella typhimurium tryptophan synthase (2008), Arch. Biochem. Biophys., 470, 8-19.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Salmonella enterica subsp. enterica serovar Typhimurium

Protein Variants

Protein Variants Comment Organism
D305A much broader substrate specificity for nucleophiles than the wild type enzyme Salmonella enterica subsp. enterica serovar Typhimurium
E109D modest but significant effects of 40 to 2000fold on the conformational equilibrium Salmonella enterica subsp. enterica serovar Typhimurium

Metals/Ions

Metals/Ions Comment Organism Structure
Cs+ has an effect on the conformational equilibrium Salmonella enterica subsp. enterica serovar Typhimurium
K+ has an effect on the conformational equilibrium Salmonella enterica subsp. enterica serovar Typhimurium
Li+ has an effect on the conformational equilibrium Salmonella enterica subsp. enterica serovar Typhimurium
Na+ has an effect on the conformational equilibrium Salmonella enterica subsp. enterica serovar Typhimurium
NH4+ has little effect on the conformational equilibrium Salmonella enterica subsp. enterica serovar Typhimurium
Rb+ has an effect on the conformational equilibrium Salmonella enterica subsp. enterica serovar Typhimurium

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Purification (Commentary)

Purification (Comment) Organism
PD-10 column chromatography, desalting Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-serine + indole
-
Salmonella enterica subsp. enterica serovar Typhimurium L-tryptophan + H2O
-
?

Synonyms

Synonyms Comment Organism
Trp synthase
-
Salmonella enterica subsp. enterica serovar Typhimurium

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Salmonella enterica subsp. enterica serovar Typhimurium