Literature summary for 4.2.1.2 extracted from

Usa, K.; Liu, Y.; Geurts, A.M.; Cheng, Y.; Lazar, J.; Baker, M.A.; Grzybowski, M.; He, Y.; Tian, Z.; Liang, M.
Elevation of fumarase attenuates hypertension and can result from a nonsynonymous sequence variation or increased expression depending on rat strain (2017), Physiol. Genomics, 49, 496-504 .

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Application

Application	Comment	Organism
medicine	elevation of total fumarase activity may attenuate the development of hypertension	Rattus norvegicus

Protein Variants

Protein Variants	Comment	Organism
K481E	the activity of fumarase is lower in Dahl salt-sensitive SS rats compared with SS.13BN rats. SS.13BN rats have a Brown Norway (BN) allele of fumarase and exhibit attenuated hypertension. The SS allele of fumarase differs from the BN allele by a K481E sequence variation	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P14408	-	-

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Release 2023.1 (January 2023)