Literature summary for 4.2.1.2 extracted from

Mechaly, A.E.; Haouz, A.; Miras, I.; Barilone, N.; Weber, P.; Shepard, W.; Alzari, P.M.; Bellinzoni, M.
Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis (2012), FEBS Lett., 586, 1606-1611.

Search for more literature for 4.2.1.2

Crystallization (Commentary)

Crystallization (Comment)	Organism
crystal structures of Mycobacterium tuberculosis Rv1098c in complex with L-malate, fumarate and the competitive inhibitor meso-tartrate is reported	Mycobacterium tuberculosis

Protein Variants

Protein Variants	Comment	Organism
S318A	mutant shows no activity	Mycobacterium tuberculosis
S318C	mutant shows no activity	Mycobacterium tuberculosis

Inhibitors

Inhibitors	Comment	Organism	Structure
meso-tartrate	-	Mycobacterium tuberculosis

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	P9WN93	-	-
Mycobacterium tuberculosis ATCC 25618	P9WN93	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
fumarate + H2O	-	Mycobacterium tuberculosis	L-malate	-	?
fumarate + H2O	-	Mycobacterium tuberculosis ATCC 25618	L-malate	-	?

Synonyms

Synonyms	Comment	Organism
class II fumarase	-	Mycobacterium tuberculosis
rv1098c	-	Mycobacterium tuberculosis

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)