Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Trypanosoma brucei |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | mitochondrial matrix | Trypanosoma brucei | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma brucei | - |
- |
- |
Trypanosoma brucei Lister 427 | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bloodstream form | enzyme is expressed in both insect and mammalian bloodstream forms of Trypanosoma brucei | Trypanosoma brucei | - |
Synonyms | Comment | Organism |
---|---|---|
3-MGCoA-H | - |
Trypanosoma brucei |
Tb427.10.4000 | - |
Trypanosoma brucei |
Tb427.10.4000 | gene locus | Trypanosoma brucei |
General Information | Comment | Organism |
---|---|---|
physiological function | the depletion of 3-MGCoA-H by RNAi affects minimally the proliferation of both insect and mammalian bloodstream forms. An excess of leucine in the culture medium causes growth defects in cells depleted of 3-MGCoA-H, which can be reestablished by mevalonate. Procyclics depleted of the 3-MGCoA-H present reduced levels of synthesized steroids relative to cholesterol that is scavenged by the parasite | Trypanosoma brucei |