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Literature summary for 4.2.1.17 extracted from
- Specific ion influences on self-association of pyruvate dehydrogenase kinase isoform 2 (PDHK2), binding of PDHK2 to the L2 lipoyl domain, and effects of the lipoyl group-binding site inhibitor, Nov3r (2008), Biochemistry, 47, 2312-2324.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | ECHS1 down-regulation contributes to high-fat diet-induced hepatic steatosis | Mus musculus |
| medicine | ECHS1 down-regulation contributes to high-fat diet-induced hepatic steatosis | Homo sapiens |
| medicine | ECHS1 down-regulation contributes to high-fat diet-induced hepatic steatosis | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| AML-12 cell | - |
Mus musculus | - |
| liver | - |
Mus musculus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ECHS1 | - |
Mus musculus |
| ECHS1 | - |
Homo sapiens |
| ECHS1 | - |
Rattus norvegicus |
| enoyl-CoA hydratase | - |
Mus musculus |
| enoyl-CoA hydratase | - |
Homo sapiens |
| enoyl-CoA hydratase | - |
Rattus norvegicus |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Rattus norvegicus | a proteomic approach is applied to examine the effect of high fat diet on the liver proteome during the progression of nonalcoholic fatty liver disease. Male rats fed an high-fat diet for 4, 12, and 24 weeks show a reduced protein level of ECHS1 | down |
| Homo sapiens | ECHS1 expression level in patients with simple steatosis is reduced | down |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | siRNA-mediated knockdown of ECHS1 in the murine hepatocyte cell line alpha mouse liver 12 demonstrate increased cellular lipid accumulation induced by free fatty acid overload. Administering ECHS1 siRNA specifically reduces the expression of ECHS1 protein in mice liver, which significantly exacerbates the hepatic steatosis induced by an high fat diet | Mus musculus |
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Release 2023.1 (January 2023)
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