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Literature summary for 4.2.1.17 extracted from

  • He, X.Y.; Yang, S.Y.; Schulz, H.
    Inhibition of enoyl-CoA hydratase by long-chain L-3-hydroxyacyl-CoA and its possible effect on fatty acid oxidation (1992), Arch. Biochem. Biophys., 298, 527-531.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(3S)-hydroxybutanoyl-CoA competitive Bos taurus
(3S)-hydroxyhexadecanoyl-CoA competitive, 50% inhibition at 0.00075 mM, 90% inhibition by 0.004 mM Bos taurus
3-ketohexadecanoyl-CoA 0.008 mM, 40% inhibition Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.009
-
trans-2-hexadecenoyl-CoA pH 8, 25°C Bos taurus
0.022
-
crotonyl-CoA pH 8, 25°C Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
crotonyl-CoA + H2O
-
Bos taurus (3S)-3-hydroxybutanoyl-CoA
-
?
trans-2-decenoyl-CoA + H2O Vmax is 8fold lower than with crotonyl-CoA Bos taurus (3S)-hydroxydecanoyl-CoA
-
?
trans-2-hexadecenoyl-CoA + H2O Vmax is 82fold lower than with crotonyl-CoA Bos taurus (3S)-hydroxyhexadecanoyl-CoA
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00035
-
(3S)-hydroxyhexadecanoyl-CoA pH 8, 25°C Bos taurus
0.037
-
(3S)-hydroxybutanoyl-CoA pH 8, 25°C Bos taurus