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Literature summary for 4.2.1.143 extracted from

  • Ren, S.; Yue, Y.; Li, Y.; Guo, X.; Wang, S.
    Functional analyses of the versicolorin B synthase gene in Aspergillus flavus (2017), MicrobiologyOpen, 6, e00471 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.2.1.143

Cloned(Commentary)

Cloned (Comment) Organism
gene alfK, encoded in the gene cluster involved in aflatoxin biosynthesis, sequence comparisons and phylogenetic analysis and tree, RT-PCR enzyme expression analysis Aspergillus flavus

Protein Variants

Protein Variants Comment Organism
additional information aflK mutant construction by gene replacement. The aflK deletion-mutant DELTAaflK exhibits a significant decrease in sclerotial production and aflatoxin biosynthesis compared with wild-type and the complementation strain DELTAaflK::aflK. The mutation DELTAaflK does not affect the ability of Aspergillus flavus to infect seeds, but downregulates aflatoxin production after seed infection Aspergillus flavus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
versiconal Aspergillus flavus
-
 versicolorin B + H2O
-
 ?
versiconal Aspergillus flavus ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167
-
 versicolorin B + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Aspergillus flavus B8NHY3
-
-
Aspergillus flavus ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167 B8NHY3
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
versiconal
-
 Aspergillus flavus versicolorin B + H2O
-
 ?
versiconal
-
 Aspergillus flavus ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167 versicolorin B + H2O
-
 ?

Synonyms

Synonyms Comment Organism
aflK
-
 Aspergillus flavus

General Information

General Information Comment Organism
malfunction conidiation phenotype and sclerotial phenotype of wild-type, enzyme deletion DELTAaflK, and complemented mutant DELTA aflK::aflK strains, overview. The aflK deletion-mutant DELTAaflK exhibits a significant decrease in sclerotial production and aflatoxin biosynthesis compared with wild-type and the complementation strain DELTAaflK::aflK. The mutation DELTAaflK does not affect the ability of Aspergillus flavus to infect seeds, but downregulates aflatoxin production after seed infection Aspergillus flavus
physiological function the enzyme is encoded by gene alfK, which is part of the gene cluster involved in aflatoxin biosynthesis. Negative role of aflK in sclerotial production. Relationship between enzyme AflK and sclerotial production in Aspergillus flavus Aspergillus flavus