Literature summary for 4.2.1.143 extracted from

Sakuno, E.; Wen, Y.; Hatabayashi, H.; Arai, H.; Aoki, C.; Yabe, K.; Nakajima, H.
Aspergillus parasiticus cyclase catalyzes two dehydration steps in aflatoxin biosynthesis (2005), Appl. Environ. Microbiol., 71, 2999-3006.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Pichia pastoris	Aspergillus parasiticus

Protein Variants

Protein Variants	Comment	Organism
additional information	truncation of the N-terminal 41-amino-acid region may not affect the substrate specificity	Aspergillus parasiticus

Organism

Organism	UniProt	Comment	Textmining
Aspergillus parasiticus	Q12062	VBS	-
Aspergillus parasiticus NRRL 2999	Q12062	VBS	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	in addition, enzyme catalyzes the conversion of 5'-oxoaverantin to (2'S,5'S)-averufin, reaction of EC 4.2.1.142, 5'-oxoaverantin cyclase	Aspergillus parasiticus	?	-	?
additional information	in addition, enzyme catalyzes the conversion of 5'-oxoaverantin to (2'S,5'S)-averufin, reaction of EC 4.2.1.142, 5'-oxoaverantin cyclase	Aspergillus parasiticus NRRL 2999	?	-	?
versiconal	i.e. (2S,3S)-2,4,6,8-tetrahydroxy-3-(2-hydroxyethyl)anthra[2,3-b]furan-5,10-dione	Aspergillus parasiticus	versicolorin B + H2O	(3aR,12bS)-8,10,12-trihydroxy-1,2,3a,12b-tetrahydroanthra[2,3-b]furo[3,2-d]furan-6,11-dione	?
versiconal	i.e. (2S,3S)-2,4,6,8-tetrahydroxy-3-(2-hydroxyethyl)anthra[2,3-b]furan-5,10-dione	Aspergillus parasiticus NRRL 2999	versicolorin B + H2O	(3aR,12bS)-8,10,12-trihydroxy-1,2,3a,12b-tetrahydroanthra[2,3-b]furo[3,2-d]furan-6,11-dione	?

Synonyms

Synonyms	Comment	Organism
VBS	-	Aspergillus parasiticus
versicolorin B synthase	-	Aspergillus parasiticus

General Information

General Information	Comment	Organism
physiological function	enzyme is involved in aflatoxin biosynthesis. A deletion mutant accumulates large amounts of 5'-oxoaverantin, 5'-hydroxyaverantin, averantin, (2'S,5'S)-averufin, and averufanin in the mycelium, leading to bright orange colour	Aspergillus parasiticus

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Release 2023.1 (January 2023)