Literature summary for 4.2.1.136 extracted from

Petrovova, M.; Tkadlec, J.; Dvoracek, L.; Streitova, E.; Licha, I.
NAD(P)H-hydrate dehydratase - a metabolic repair enzyme and its role in Bacillus subtilis stress adaptation (2014), PLoS ONE, 9, e112590 .

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Protein Variants

Protein Variants	Comment	Organism
additional information	construction of a Bacillus subtilis168 yxkO gene knockout mutant encoding a metabolite repair enzyme, transfer of the insertional mutation of the mini-Tn10 transposon to the yxkO gene from an asporogenic genetic background from a previously prepared mutant, for inactivation of the yxkO gene, an integrative vector pMUTIN4 is used. Analysis of gene yxkO knockout phenotype, overview	Bacillus subtilis

Organism

Organism	UniProt	Comment	Textmining
Bacillus subtilis	P94368	-	-
Bacillus subtilis 168	P94368	-	-

Synonyms

Synonyms	Comment	Organism
ADP-dependent (S)-NAD(P)H-hydrate dehydratase	UniProt	Bacillus subtilis
ADP/ATP-dependent NAD(P)H-hydrate dehydratase	-	Bacillus subtilis
BSU38720	-	Bacillus subtilis
More	cf. EC 4.2.1.93	Bacillus subtilis
NAD(P)H-hydrate dehydratase	-	Bacillus subtilis
NNRD	-	Bacillus subtilis
YxkO	-	Bacillus subtilis

General Information

General Information	Comment	Organism
malfunction	the Bacillus subtilis 168 osmosensitive mutant, defective in the yxkO gene, gene yxkO knockout phenotype, overview. Changes in the protein value caused by yxkO disruption are also recorded for GroEL. In the mutant, the increase of protein level occurred in non-stressed conditions, as well when compared to the wild-type due to extension of the lag phase and the decline of the renewing of isocitrate dehydrogenase levels in the mutant according to wild-type after stress exposure, which denotes to failure of stress adaptation and triggers increased levels of GroEL as a result of the devastating effects of both stresses on cellular proteins. Identification of differences in protein levels under osmotic stress and ethanol stress, overview	Bacillus subtilis
physiological function	the regulatory adaptive system called general stress response (GSR) is dependent on the SigB transcription factor in Bacillus sp.. The GSR is one of the largest regulon in Bacillus sp., including about 100 genes. The yxkO gene (encoding a putative ribokinase) is recently assigned in vitro as an ADP/ATP-dependent NAD(P)H-hydrate dehydratase and belongs to the SigB operon. YxkO has an impact on the activity of SigB-dependent Pctc promoter and adaptation to osmotic and ethanol stress and potassium limitation respectively. The enzyme might play a significant role in the survival of stressed cells	Bacillus subtilis

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Release 2023.1 (January 2023)