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Literature summary for 4.2.1.125 extracted from

  • Kushiro, T.; Ohno, Y.; Shibuya, M.; Ebizuka, Y.
    In vitro conversion of 2,3-oxidosqualene into dammarenediol by Panax ginseng microsomes (1997), Biol. Pharm. Bull., 20, 292-294.
    View publication on PubMed
Search for more literature for 4.2.1.125

Inhibitors

Inhibitors Comment Organism Structure
3-((3-cholamidopropyl)dimethylammonio)-1-propanesulfonate i.e. CHAPS, 0.1%, 30% residual activity Panax ginseng
deoxycholate 0.1%, 92% residual activity Panax ginseng
n-octyl-beta-D-glucoside 0.1%, 58% residual activity Panax ginseng
Triton X-100 0.1%, 64% residual activity Panax ginseng
Tween 20 0.1%, 23% residual activity Panax ginseng

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome exclusive localization Panax ginseng
-
-

Organism

Organism UniProt Comment Textmining
Panax ginseng
-
-
-

Reaction

Reaction Comment Organism Reaction ID
dammarenediol II = (3S)-2,3-epoxy-2,3-dihydrosqualene + H2O cyclization initiated by protonation at the oxirane ring proceeds to form tetracycles. The resulting dammarenyl cation is trapped by stereospecific addition of water at C20 without further rearrangement Panax ginseng
a

Source Tissue

Source Tissue Comment Organism Textmining
root hairy root Panax ginseng
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(3S)-2,3-oxidosqualene + H2O substrate is folded in a pre-chair-chair-chair conformation Panax ginseng (20S)-dammarenediol
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Panax ginseng

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
-
 Panax ginseng