Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(R)-methylenecyclopropylformyl-CoA | methylenecyclopropylformyl-CoA is a better inhibitor for enoyl-CoA hydratase 2 than for enoyl-CoA hydratase 1 | Rattus norvegicus | |
(S)-methylenecyclopropylformyl-CoA | methylenecyclopropylformyl-CoA is a better inhibitor for enoyl-CoA hydratase 2 than for enoyl-CoA hydratase 1 | Rattus norvegicus | |
3-octynoyl-CoA | irreversible inhibitor of enoyl-CoA hydratase 2 | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
peroxisome | - |
Rattus norvegicus | 5777 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | the beta-oxidation in mitochondria involves a (3S)-hydroxyacyl-CoA intermediate, while the beta-oxidation in peroxisomes has a (3R)-hydroxyacyl-CoA intermediate. The enzymes responsible for the formation of these two different intermediates are enoyl-CoA hydratase 1 (ECH1) in mitochondria and enoyl-CoA hydratase 2 (ECH2) in peroxisomes | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the beta-oxidation in mitochondria involves a (3S)-hydroxyacyl-CoA intermediate, while the beta-oxidation in peroxisomes has a (3R)-hydroxyacyl-CoA intermediate. The enzymes responsible for the formation of these two different intermediates are enoyl-CoA hydratase 1 (ECH1) in mitochondria and enoyl-CoA hydratase 2 (ECH2) in peroxisomes | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ECH2 | - |
Rattus norvegicus |
enoyl-CoA hydratase 2 | - |
Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.041 | - |
(R)-methylenecyclopropylformyl-CoA | 25°C | Rattus norvegicus | |
0.053 | - |
(S)-methylenecyclopropylformyl-CoA | 25°C | Rattus norvegicus | |
0.065 | - |
3-octynoyl-CoA | 25°C | Rattus norvegicus |