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Literature summary for 4.2.1.115 extracted from

  • Merkx-Jacques, A.; Obhi, R.K.; Bethune, G.; Creuzenet, C.
    The Helicobacter pylori flaA1 and wbpB genes control lipopolysaccharide and flagellum synthesis and function (2004), J. Bacteriol., 186, 2253-2265.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.2.1.115

Cloned(Commentary)

Cloned (Comment) Organism
gene flaA1, DNA and amino acid sequence determination, expression analysis Helicobacter pylori

Protein Variants

Protein Variants Comment Organism
additional information construction of flaA1 knockout mutant by gene disruption in strain NCTC 11637, the nonmotile mutant exhibits altered lipopolysaccharides, with loss of most O-antigen and core modification, and increased sensitivity to sodium dodecyl sulfate compared to wild-type bacteria. The flaA1 mutant produces flagellins but no flagellum. Phynotype, detailed overview Helicobacter pylori

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Helicobacter pylori the enzyme is involved in lipopolysaccharide biosynthesis, flagellum assembly, or protein glycosylation, and might play an important role in the pathogenesis of Helicobacter pylori. It is at the interface between several pathways that govern the expression of different virulence factors synthesizing sugar derivatives dedicated to the glycosylation of proteins which are involved in lipopolysaccharide and flagellum production with glycosylation regulating the activity of these proteins ?
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 ?
additional information Helicobacter pylori the enzyme is involved in lipopolysaccharide biosynthesis, flagellum assembly, or protein glycosylation, and might play an important role in the pathogenesis of Helicobacter pylori. It is at the interface between several pathways that govern the expression of different virulence factors synthesizing sugar derivatives dedicated to the glycosylation of proteins which are involved in LPS and flagellum production with glycosylation regulating the activity of these proteins ?
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 ?
additional information Helicobacter pylori SS1 the enzyme is involved in lipopolysaccharide biosynthesis, flagellum assembly, or protein glycosylation, and might play an important role in the pathogenesis of Helicobacter pylori. It is at the interface between several pathways that govern the expression of different virulence factors synthesizing sugar derivatives dedicated to the glycosylation of proteins which are involved in LPS and flagellum production with glycosylation regulating the activity of these proteins ?
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 ?
additional information Helicobacter pylori NCTC 11637 the enzyme is involved in lipopolysaccharide biosynthesis, flagellum assembly, or protein glycosylation, and might play an important role in the pathogenesis of Helicobacter pylori. It is at the interface between several pathways that govern the expression of different virulence factors synthesizing sugar derivatives dedicated to the glycosylation of proteins which are involved in lipopolysaccharide and flagellum production with glycosylation regulating the activity of these proteins ?
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 ?

Organism

Organism UniProt Comment Textmining
Helicobacter pylori Q6VYQ5 gene flaA1
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Helicobacter pylori Q6VYQ6
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Helicobacter pylori NCTC 11637 Q6VYQ6
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Helicobacter pylori SS1 Q6VYQ5 gene flaA1
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is involved in lipopolysaccharide biosynthesis, flagellum assembly, or protein glycosylation, and might play an important role in the pathogenesis of Helicobacter pylori. It is at the interface between several pathways that govern the expression of different virulence factors synthesizing sugar derivatives dedicated to the glycosylation of proteins which are involved in lipopolysaccharide and flagellum production with glycosylation regulating the activity of these proteins Helicobacter pylori ?
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 ?
additional information the enzyme is involved in lipopolysaccharide biosynthesis, flagellum assembly, or protein glycosylation, and might play an important role in the pathogenesis of Helicobacter pylori. It is at the interface between several pathways that govern the expression of different virulence factors synthesizing sugar derivatives dedicated to the glycosylation of proteins which are involved in LPS and flagellum production with glycosylation regulating the activity of these proteins Helicobacter pylori ?
-
 ?
additional information the enzyme is involved in lipopolysaccharide biosynthesis, flagellum assembly, or protein glycosylation, and might play an important role in the pathogenesis of Helicobacter pylori. It is at the interface between several pathways that govern the expression of different virulence factors synthesizing sugar derivatives dedicated to the glycosylation of proteins which are involved in LPS and flagellum production with glycosylation regulating the activity of these proteins Helicobacter pylori SS1 ?
-
 ?
additional information the enzyme is involved in lipopolysaccharide biosynthesis, flagellum assembly, or protein glycosylation, and might play an important role in the pathogenesis of Helicobacter pylori. It is at the interface between several pathways that govern the expression of different virulence factors synthesizing sugar derivatives dedicated to the glycosylation of proteins which are involved in lipopolysaccharide and flagellum production with glycosylation regulating the activity of these proteins Helicobacter pylori NCTC 11637 ?
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 ?

Synonyms

Synonyms Comment Organism
FlaA1
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 Helicobacter pylori