Literature summary for 4.2.1.10 extracted from

Tizon, L.; Maneiro, M.; Peon, A.; Otero, J.M.; Lence, E.; Poza, S.; van Raaij, M.J.; Thompson, P.; Hawkins, A.R.; Gonzalez-Bello, C.
Irreversible covalent modification of type I dehydroquinase with a stable Schiff base (2015), Org. Biomol. Chem., 13, 706-716 .

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Crystallization (Commentary)

Crystallization (Comment)	Organism
in complex with inhibitor (3S,5R,7R,8S)-5,7,8-trihydroxy-1-oxaspiro[2.5]octane-5-carboxylic acid, to 1.4 A resolution. The ligand is covalently attached to the essential Lys170 residue by formation of a stable Schiff base	Salmonella enterica subsp. enterica serovar Typhi

Inhibitors

Inhibitors	Comment	Organism	Structure
(3S,5R,7R,8S)-5,7,8-trihydroxy-1-oxaspiro[2.5]octane-5-carboxylic acid	time-dependent irreversible inhibitor, % inhibition in 30 min at 0.274 mM	Salmonella enterica subsp. enterica serovar Typhi

Organism

Organism	UniProt	Comment	Textmining
Salmonella enterica subsp. enterica serovar Typhi	P24670	-	-

Synonyms

Synonyms	Comment	Organism
aroD	-	Salmonella enterica subsp. enterica serovar Typhi

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Release 2023.1 (January 2023)