Literature summary for 4.2.1.10 extracted from

Payne, R.J.; Peyrot, F.; Kerbarh, O.; Abell, A.D.; Abell, C.
Rational design, synthesis, and evaluation of nanomolar type II dehydroquinase inhibitors (2007), ChemMedChem, 2, 1015-1029.

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Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	the in silico design, synthesis, and biological evaluation of ten potent type II dehydroquinase inhibitors are described. These compounds contain an anhydroquinate core, incorporated as a mimic of the enolate reaction intermediate. This substructure is attached by a variety of linking units to a terminal phenyl group that binds in an adjacent pocket. Inhibitors are synthesised from (-)-quinic acid using palladium-catalysed Stille and carboamidation chemistry. Several inhibitors exhibited nanomolar inhibition constants	Mycobacterium tuberculosis
additional information	the in silico design, synthesis, and biological evaluation of ten potent type II dehydroquinase inhibitors are described. These compounds contain an anhydroquinate core, incorporated as a mimic of the enolate reaction intermediate. This substructure is attached by a variety of linking units to a terminal phenyl group that binds in an adjacent pocket. Inhibitors are synthesised from (-)-quinic acid using palladium-catalysed Stille and carboamidation chemistry. Several inhibitors exhibited nanomolar inhibition constants	Streptomyces coelicolor

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	-	-	-
Streptomyces coelicolor	-	-	-

Synonyms

Synonyms	Comment	Organism
EC 4.2.1.10	-	Mycobacterium tuberculosis
EC 4.2.1.10	-	Streptomyces coelicolor

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Release 2023.1 (January 2023)