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Literature summary for 4.2.1.1 extracted from
- Carbonic anhydrase inhibitory properties of some uracil derivatives (2017), J. Enzyme Inhib. Med. Chem., 32, 74-77 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,3-dimethylpyrimidine-2,4(1H,3H)-dione | inhibition of isozyme hCA I; inhibition of isozyme hCA II | Homo sapiens |  |
| 5,6-diamino-1,3-dimethyluracil | inhibition of isozyme hCA I; inhibition of isozyme hCA II | Homo sapiens | |
| 5-(hydroxymethyl)pyrimidine-2,4(1H,3H)-dione | inhibition of isozyme hCA I | Homo sapiens | |
| 5-bromo-1-(4-methylbenzene-1-sulfonyl)pyrimidine-2,4(1H,3H)-dione | inhibition of isozyme hCA I; inhibition of isozyme hCA II | Homo sapiens | |
| 5-bromo-1-(methanesulfonyl)pyrimidine-2,4(1H,3H)-dione | inhibition of isozyme hCA I; inhibition of isozyme hCA II | Homo sapiens | |
| 5-fluorouracil | - |
Homo sapiens | |
| 6-amino-1,3-dimethyluracil | inhibition of isozyme hCA I; inhibition of isozyme hCA II | Homo sapiens | |
| 6-amino-5-bromouracil | - |
Homo sapiens | |
| 6-amino-5-chlorouracil | - |
Homo sapiens | |
| 6-methylpyrimidine-2,4(1H,3H)-dione | inhibition of isozyme hCA I | Homo sapiens | |
| Benzene | - |
Homo sapiens | |
| benzene-1,2-diol | inhibition of isozyme hCA I | Homo sapiens | |
| benzene-1,3-diol | inhibition of isozyme hCA I | Homo sapiens | |
| catechol | inhibition of isozyme hCA II | Homo sapiens | |
| Isoorotic acid | inhibition of isozyme hCA I; inhibition of isozyme hCA II | Homo sapiens | |
| additional information | some uracil derivatives have carbonic anhydrase inhibitory properties, overview; some uracil derivatives have carbonic anhydrase inhibitory properties, overview | Homo sapiens | |
| Orotic acid | inhibition of isozyme hCA I; inhibition of isozyme hCA II | Homo sapiens | |
| phenol | inhibition of isozyme hCA I; inhibition of isozyme hCA II | Homo sapiens | |
| resorcinol | inhibition of isozyme hCA II | Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | required, metalloenzyme | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| H2CO3 | Homo sapiens | - |
CO2 + H2O | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P00915 | - |
- |
| Homo sapiens | P00918 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| H2CO3 | - |
Homo sapiens | CO2 + H2O | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| hCA I | - |
Homo sapiens |
| HCA II | - |
Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000085 | - |
6-amino-1,3-dimethyluracil | pH 7.4, temperature not specified in the publication | Homo sapiens | |
| 0.0001035 | - |
5,6-diamino-1,3-dimethyluracil | pH 7.4, temperature not specified in the publication | Homo sapiens | |
| 0.0001715 | - |
6-amino-1,3-dimethyluracil | pH 7.4, temperature not specified in the publication | Homo sapiens | |
| 0.000236 | - |
5,6-diamino-1,3-dimethyluracil | pH 7.4, temperature not specified in the publication | Homo sapiens | |
| 0.0004585 | - |
Isoorotic acid | pH 7.4, temperature not specified in the publication | Homo sapiens | |
| 0.0007325 | - |
Orotic acid | pH 7.4, temperature not specified in the publication | Homo sapiens | |
| 0.0055 | - |
phenol | pH 7.4, temperature not specified in the publication | Homo sapiens | |
| 0.0077 | - |
resorcinol | pH 7.4, temperature not specified in the publication | Homo sapiens | |
| 0.0099 | - |
catechol | pH 7.4, temperature not specified in the publication | Homo sapiens | |
| 0.0102 | - |
phenol | pH 7.4, temperature not specified in the publication | Homo sapiens | |
| 0.01083 | - |
5-bromo-1-(4-methylbenzene-1-sulfonyl)pyrimidine-2,4(1H,3H)-dione | pH 7.4, temperature not specified in the publication | Homo sapiens | |
| 0.02888 | - |
5-bromo-1-(4-methylbenzene-1-sulfonyl)pyrimidine-2,4(1H,3H)-dione | pH 7.4, temperature not specified in the publication | Homo sapiens | |
| 0.04951 | - |
5-(hydroxymethyl)pyrimidine-2,4(1H,3H)-dione | pH 7.4, temperature not specified in the publication | Homo sapiens | |
| 0.05776 | - |
6-methylpyrimidine-2,4(1H,3H)-dione | pH 7.4, temperature not specified in the publication | Homo sapiens | |
| 0.1664 | - |
1,3-dimethylpyrimidine-2,4(1H,3H)-dione | pH 7.4, temperature not specified in the publication | Homo sapiens | |
| 0.3162 | - |
1,3-dimethylpyrimidine-2,4(1H,3H)-dione | pH 7.4, temperature not specified in the publication | Homo sapiens | |
| 0.428 | - |
5-bromo-1-(methanesulfonyl)pyrimidine-2,4(1H,3H)-dione | pH 7.4, temperature not specified in the publication | Homo sapiens | |
| 0.645 | - |
5-bromo-1-(methanesulfonyl)pyrimidine-2,4(1H,3H)-dione | pH 7.4, temperature not specified in the publication | Homo sapiens | |
| 0.795 | - |
benzene-1,3-diol | pH 7.4, temperature not specified in the publication | Homo sapiens | |
| 1.432 | - |
Isoorotic acid | pH 7.4, temperature not specified in the publication | Homo sapiens | |
| 1.682 | - |
Orotic acid | pH 7.4, temperature not specified in the publication | Homo sapiens | |
| 4.003 | - |
benzene-1,2-diol | pH 7.4, temperature not specified in the publication | Homo sapiens | |
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